MovDisordV3, Main, Exploration, bibRecord, 000B13

Alcohol challenge and sensitivity to change of The Essential Tremor Rating Assessment Scale (TETRAS)

Identifieur interne : 000B13 ( Main/Exploration ); précédent : 000B12; suivant : 000B14

Alcohol challenge and sensitivity to change of The Essential Tremor Rating Assessment Scale (TETRAS)

Auteurs : Bernhard Voller [Autriche] ; Emily Lines ; Gayle Mccrossin ; Aaron Artiles ; Sule Tinaz ; Codrin Lungu ; Mark Hallett ; Dietrich Haubenberger [Autriche]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:4189108

English descriptors

KwdEn :
- Aged, Alcohols (diagnostic use), Essential Tremor (diagnosis), Ethanol (diagnostic use), Female, Humans, Male, Middle Aged.
MESH :
- chemical , diagnostic use : Alcohols, Ethanol.
- diagnosis : Essential Tremor.
- Aged, Female, Humans, Male, Middle Aged.

Abstract

Background

The Essential Tremor (ET) Rating Assessment Scale (TETRAS) has shown excellent inter- and intra-rater reliability. To assess the scale’s ability to detect changes in tremor severity, we compared TETRAS performance with standard postural tremor accelerometry during a standardized ethanol challenge.

Methods

Fifteen adult ET patients received a single oral ethanol dose calculated to reach 0.05 g/dl breath alcohol content (brAC) on two different study days. Two investigators independently assessed the effects with accelerometry on one day and with TETRAS on another day. Measurements were taken at 8 time-points (2 time-points baseline and 6 time-points up to 2 hours post ethanol). Further outcome measures included brAC readings at the same time points.

Results

Because correlation between TETRAS and accelerometry revealed a logarithmic relation, for all comparisons, accelerometry data were log-transformed and a cumulative score logACC(R+L) was calculated. Correlation between logACC(R+L) and TETRAS was significant (r= 0.57, p<0.01). Repeated measures ANOVA for both TETRAS and accelerometry before and after ethanol showed a significant effect of time-point (F=34.6, p<0.01; F=13.5, p<0.01). Corrected post-hoc tests showed a difference between baseline and each of the following 6 time-points. TETRAS and brAC were significantly correlated (r=−0.29, p<0.01). Intra-rater test-retest analysis between baseline measures showed high correlation (ICC=0.974, p<0.001). The ethanol challenge showed excellent reproducibility.

Conclusion

We demonstrated sensitivity of the TETRAS performance scale to change after a therapeutic intervention. Our study provides responsiveness validity for TETRAS, further establishing its potential as a valid instrument for ET evaluation in both clinical and research settings.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189108

DOI: 10.1002/mds.25667
PubMed: 24123358
PubMed Central: 4189108

Affiliations:

Autriche

Le document en format XML

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<author><name sortKey="Voller, Bernhard" sort="Voller, Bernhard" uniqKey="Voller B" first="Bernhard" last="Voller">Bernhard Voller</name>
<affiliation><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health</nlm:aff>
<wicri:noCountry code="subfield">National Institutes of Health</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology, Medical University of Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna</wicri:regionArea>
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<author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name>
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<author><name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alcohol challenge and sensitivity to change of The Essential Tremor Rating Assessment Scale (TETRAS)</title>
<author><name sortKey="Voller, Bernhard" sort="Voller, Bernhard" uniqKey="Voller B" first="Bernhard" last="Voller">Bernhard Voller</name>
<affiliation><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health</nlm:aff>
<wicri:noCountry code="subfield">National Institutes of Health</wicri:noCountry>
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<wicri:noCountry code="subfield">National Institutes of Health</wicri:noCountry>
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<affiliation><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health</nlm:aff>
<wicri:noCountry code="subfield">National Institutes of Health</wicri:noCountry>
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<affiliation><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health</nlm:aff>
<wicri:noCountry code="subfield">National Institutes of Health</wicri:noCountry>
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<author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name>
<affiliation><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health</nlm:aff>
<wicri:noCountry code="subfield">National Institutes of Health</wicri:noCountry>
</affiliation>
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<author><name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name>
<affiliation><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health</nlm:aff>
<wicri:noCountry code="subfield">National Institutes of Health</wicri:noCountry>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
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<imprint><date when="2013">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Alcohols (diagnostic use)</term>
<term>Essential Tremor (diagnosis)</term>
<term>Ethanol (diagnostic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Alcohols</term>
<term>Ethanol</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Essential Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The Essential Tremor (ET) Rating Assessment Scale (TETRAS) has shown excellent inter- and intra-rater reliability. To assess the scale’s ability to detect changes in tremor severity, we compared TETRAS performance with standard postural tremor accelerometry during a standardized ethanol challenge.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Fifteen adult ET patients received a single oral ethanol dose calculated to reach 0.05 g/dl breath alcohol content (brAC) on two different study days. Two investigators independently assessed the effects with accelerometry on one day and with TETRAS on another day. Measurements were taken at 8 time-points (2 time-points baseline and 6 time-points up to 2 hours post ethanol). Further outcome measures included brAC readings at the same time points.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Because correlation between TETRAS and accelerometry revealed a logarithmic relation, for all comparisons, accelerometry data were log-transformed and a cumulative score logACC(R+L) was calculated. Correlation between logACC(R+L) and TETRAS was significant (r= 0.57, p<0.01). Repeated measures ANOVA for both TETRAS and accelerometry before and after ethanol showed a significant effect of time-point (F=34.6, p<0.01; F=13.5, p<0.01). Corrected post-hoc tests showed a difference between baseline and each of the following 6 time-points. TETRAS and brAC were significantly correlated (r=−0.29, p<0.01). Intra-rater test-retest analysis between baseline measures showed high correlation (ICC=0.974, p<0.001). The ethanol challenge showed excellent reproducibility.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">We demonstrated sensitivity of the TETRAS performance scale to change after a therapeutic intervention. Our study provides responsiveness validity for TETRAS, further establishing its potential as a valid instrument for ET evaluation in both clinical and research settings.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>Autriche</li>
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<tree><noCountry><name sortKey="Artiles, Aaron" sort="Artiles, Aaron" uniqKey="Artiles A" first="Aaron" last="Artiles">Aaron Artiles</name>
<name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name>
<name sortKey="Lines, Emily" sort="Lines, Emily" uniqKey="Lines E" first="Emily" last="Lines">Emily Lines</name>
<name sortKey="Lungu, Codrin" sort="Lungu, Codrin" uniqKey="Lungu C" first="Codrin" last="Lungu">Codrin Lungu</name>
<name sortKey="Mccrossin, Gayle" sort="Mccrossin, Gayle" uniqKey="Mccrossin G" first="Gayle" last="Mccrossin">Gayle Mccrossin</name>
<name sortKey="Tinaz, Sule" sort="Tinaz, Sule" uniqKey="Tinaz S" first="Sule" last="Tinaz">Sule Tinaz</name>
</noCountry>
<country name="Autriche"><noRegion><name sortKey="Voller, Bernhard" sort="Voller, Bernhard" uniqKey="Voller B" first="Bernhard" last="Voller">Bernhard Voller</name>
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<name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name>
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Movement Disorders (revue)

Alcohol challenge and sensitivity to change of The Essential Tremor Rating Assessment Scale (TETRAS)

Alcohol challenge and sensitivity to change of The Essential Tremor Rating Assessment Scale (TETRAS)

Source :

English descriptors

Abstract

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